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The antiemetic regimen for moderately emetogenic drugs includes dexamethosone and a 5-ht3 antagonist palonosetron is preferred with or without lorazepam; consider adding aprepitant for select patients those receiving carboplatin, cyclophosphamide, doxorubixin, epirubicin, ifosfamide, irinotecan, or methotrexate .

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if methotrexate induced lung disease is suspected treatment with corticosteroids should be initiated and treatment with methotrexate should not be restarted.

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